Two-tower models for genomic prediction of reproductive outcomes and sex-specific fertility liabilities: simulation insights biorxiv.org 2026-07-09 Many biological characteristics arise by interactions between more than one biological organism or unit.
Improving coral oxidative stress assessments through compartment-specific lipid peroxidation measurements and increased methodological standardization biorxiv.org 2026-07-09 Lipid peroxidation (LPO) is widely used as a biomarker of oxidative stress in coral bleaching research, yet its measurement remains poorly standardize
Coated Bacterial Enzymes: A one-step approach for enzymatic purification and immobilization biorxiv.org 2026-07-09 The purification of industrial enzymes typically relies on costly, multi-step chromatographic protocols.
Variational Autoencoder-enabled High-throughput Drug Screening for HIV Latency Modulators predicted through Noise in Gene Expression biorxiv.org 2026-07-09 Due to its ability to establish a pool of undetectable and latently infected cells that can initiate viral production through random reactivation, a c
Directed evolution of the Fe-nitrogenase for CO2 reduction to hydrocarbons biorxiv.org 2026-07-09 The iron (Fe) nitrogenase drives bacterial methane (CH4) formation by converting carbon dioxide (CO2) to CH4 in a single enzymatic step.
Expanding Microgel Parameters to Model the Tumor Microenvironment and Examine Temozolomide Resistance in Glioblastoma biorxiv.org 2026-07-09 Glioblastoma (GBM) is a highly aggressive brain tumor with a five-year survival rate of less than 5%.
Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states biorxiv.org 2026-07-09 Adaptive deep brain stimulation (aDBS) relies on physiological biomarkers to infer motor state and guide therapeutic stimulation in Parkinson's diseas
Vibration's frequency and intensity for optimal setup for enhancement bone response in small rodents: A systematic review and Bayesian network meta-analysis biorxiv.org 2026-07-09 Low-intensity vibration (LIV) is a non-invasive mechanical stimulus capable of regulating skeletal adaptation and cellular signaling pathways involved
A non-enzymatic role for METTL3 as an Androgen Receptor co-regulator that promotes prostate cancer proliferation. biorxiv.org 2026-07-09 Metastatic prostate cancer (PCa) continues to be a major cause of death in males, despite advances in treatment.
An immunocompetent osteoblastic model of mammary cancer bone metastasis established by syngeneic intratibial injection of PyMT mammary carcinoma cells in FVB/N mice biorxiv.org 2026-07-09 Osteoblastic bone metastasis, in which disseminated tumor cells drive net bone formation, is a clinically distinct and mechanistically underexplored f
Predicting subclonal TP53 mutations from tumor spatial transcriptomics data using a graph convolutional neural network biorxiv.org 2026-07-09 Spatial transcriptomics (ST) has revolutionized our understanding of tumor biology but inherently lacks information on the upstream somatic driver mut
Correlation of OCT-Based Radiomic Signatures With Dose-Associated Radiation Response in Tumor Spheroids biorxiv.org 2026-07-09 Background: Three-dimensional tumor spheroids are an established radiobiology model, but scalable, reproducible readouts of dose-dependent radiation r
Leveraging Homologous Recombination Deficiency via the Repositioned Prodrug CB1954 biorxiv.org 2026-07-09 Homologous recombination deficiency (HRD) is an actionable vulnerability found in a substantial fraction of human cancers, yet current HRD-directed th
Making the most out of it: shallow genome-skimming possibilities for the systematics of prickly lineages of Solanum (Solanaceae) biorxiv.org 2026-07-09 Premise: Genome skimming (GS) is a cost-effective approach for plant phylogenomics, but its ability to recover informative datasets from different gen
Characterisation of the new microalgal protein xATPA related to the F-type ATP synthase α subunit, from the ecosystem to the molecule biorxiv.org 2026-07-09 Microalgal metabolism relies on their chloroplasts, and involves both nucleus and plastidial-encoded proteins of various evolutionary origins.
miR319 promotes de novo shoot regeneration by repressing LsTCP4 in lettuce biorxiv.org 2026-07-09 Plant regeneration is a major determinant of transformation and genome-editing efficiency, yet the endogenous regulatory networks controlling regenera
Characterising AlphaFold 3s ability to predict T cellantigen specificity biorxiv.org 2026-07-09 T cells are a key part of the adaptive immune system.
Domain-specific proteome remodeling defines mouse myelin aging biorxiv.org 2026-07-09 Myelin, once regarded as a static insulating structure, is now recognized as a dynamic component of the nervous system, capable of remodeling in respo
A pooled image-based CRISPR screen identifies EAF1 as a T. gondii modulator of ESCRT subversion. biorxiv.org 2026-07-09 Intracellular pathogens remodel host cells by redirecting cellular machinery to the host-pathogen interface.
Tissue-specific consequences of impaired RNA surveillance converge on mitochondrial homeostasis biorxiv.org 2026-07-09 RNA surveillance pathways maintain transcriptome integrity by eliminating aberrant, excess, and non-functional RNAs, yet it remains unclear whether di
Aclarubicin disrupts RNA polymerase II progression at replication-coupled histone genes biorxiv.org 2026-07-09 Anthracyclines are highly effective chemotherapeutic agents that cause DNA and chromatin damage.
A Sac7-Rho1 axis at the plasma membrane controls clathrin-independent endocytosis biorxiv.org 2026-07-09 In eukaryotes, our understanding of clathrin-independent endocytosis (CIE) lags far behind that of clathrin-mediated endocytosis (CME).
Mechanical strain of the intestinal epithelium directs absorptive lineage maturation biorxiv.org 2026-07-09 The intestinal epithelium is continuously subjected to a variety of mechanical forces, including extrinsic peristaltic contractions and intrinsic tens
SOLAR Mediates Lysosomal Membrane Repair and Redox Defense biorxiv.org 2026-07-09 Lysosomal damage is increasingly recognized as a hallmark of aging.
Measurement of a panel of 21 steroids in a quantitative assay in human plasma, adipose tissue, and fecal samples using ultra-high-performance liquid chromatography-tandem mass spectrometry biorxiv.org 2026-07-09 Comprehensive detection of steroids, beyond the limited panels typically analyzed in clinical chemistry laboratories, has become increasingly importan
Estimating Muscle Parameters via Hierarchical Bayesian Inference biorxiv.org 2026-07-09 Musculoskeletal models are widely used to relate muscle mechanics to movement patterns in biomechanics.
Photopatterned spatiotemporal organisation and in situ differentiation of 3D human cortical networks biorxiv.org 2026-07-09 Modelling human cortical microcircuitry in vitro requires platforms that recapitulate both the compositional complexity and spatial architecture of de
qg: Configuration-Driven, Multi-Vendor Acquisition Queue Generation with Reproducible Run-Order and QC Control for Mass Spectrometry biorxiv.org 2026-07-09 Mass spectrometry laboratories must turn lists of submitted samples into acquisition queues.
Protein hydration and druggability biorxiv.org 2026-07-08 A priori assessment of target proteins' druggability remains an unsolved problem in the field of drug development.
Emergence of large-scale polar microtubule swarms for dense molecular transport biorxiv.org 2026-07-08 Microtubules (MTs) and their motor proteins collectively harness chemical energy to generate mechanical work, driving some of the most coordinated sel