Phasic arousal sharpens, rather than amplifies, goal-dependent feedback control biorxiv.org 2026-07-07 Voluntary movements tolerate variability that does not threaten the goal: when reaching toward a wide target the hand can drift sideways, whereas a na
Rheumatoid Arthritis-associated IgG N-glycan agalactosylation diminishes neutrophilic inflammation by reducing FcgammaR binding and downstream signaling biorxiv.org 2026-07-07 The IgG Fc chain carries a single N-linked glycan which may undergo changes.
PSGL-1 blockade delays relapse to BRAF/MEK inhibition in cutaneous melanoma biorxiv.org 2026-07-07 Advanced BRAF-mutant cutaneous melanoma can be treated with targeted therapy when immune checkpoint inhibitors (ICIs) fail or are not a feasible optio
NK-like and networked CD8+ T cell immunity mediates exceptional HIV control biorxiv.org 2026-07-07 Durable treatment-free remission remains a defining goal for people living with HIV (PLWH).
Ancient and current association of the Trichinella complex with negative-sense and double-stranded RNA viruses biorxiv.org 2026-07-07 The earliest records of Trichinellosis might be found in bibles that recommend against pork consumption due to the spread of a disease that resembles
Reverse genetics and comparative pathogenesis of Lone star virus. biorxiv.org 2026-07-07 Lone star virus (LSV) is a bandavirus first isolated from Amblyomma americanum ticks in the United States (U.S.) and is phylogenetically related to se
Progressive Lineage Restriction of Bergmann Glia-like Progenitors during Postnatal Cerebellar Development biorxiv.org 2026-07-07 Bergmann glia-like progenitors (BGLPs) are transient astroglial progenitors in the postnatal cerebellum, but how their lineage potential changes durin
Humans use optimal eye movements to facilitate mental rotation of objects biorxiv.org 2026-07-07 The ability to mentally rotate objects is a fundamental feature of human cognition, and humans can use this ability to make choices about objects base
Masitinib is an oral, brain penetrant inhibitor of microglial and mast cell activity with neuroprotective potential in progressive forms of multiple sclerosis biorxiv.org 2026-07-07 Introduction: Progressive multiple sclerosis (MS), including primary progressive MS (PPMS) and non-active secondary progressive MS (nSPMS), remains an
Optical pooled screening of a bacterial transposon mutagenesis library biorxiv.org 2026-07-07 Transposon mutagenesis is a powerful method to create deep libraries of genetically diverse cells.
A foundation model enables prediction of natural product molecular properties, bioactivity, and structural similarity from biosynthetic gene cluster sequence biorxiv.org 2026-07-07 Genome mining is a powerful technique in natural product discovery, where biosynthetic gene clusters that are likely to produce novel or desirable nat
The molecular triggers of human labour: a longitudinal plasma proteomics study biorxiv.org 2026-07-07 Spontaneous labour onset is a precisely timed physiological transition that determines outcomes for millions of pregnancies annually, yet its upstream
Plasmid-encoded host reprogramming promotes plasmid dissemination biorxiv.org 2026-07-07 Conjugative plasmids are major drivers of antibiotic resistance dissemination, yet how newly transferred plasmids establish in recipient cells remains
Detrimental effects of advanced glycation end-products (AGEs) on a human neuromuscular junction co-culture model biorxiv.org 2026-07-08 The neuromuscular junction (NMJ) is a specialised synapse between motor neurons and skeletal muscle, and its progressive deterioration contributes to
Nuclear-BRITE: an enhanced MS2 system for live-cell imaging of nuclear RNAs biorxiv.org 2026-07-08 The MS2 system has been widely adopted for live-cell single molecule imaging of mRNA, but is of limited applicability for RNAs present in the cell nuc
The immediate cellular response to whole-genome doubling is conserved across polyploid contexts biorxiv.org 2026-07-08 Polyploid cells, which contain more than two copies of the genome, are widely present across plants and animals, where they are often found in tissues
Regulation of de- and reciliation by KRAS during muscle cell differentiation biorxiv.org 2026-07-07 The primary cilium has been implicated in multiple developmental processes, such as cell migration and asymmetric cell division of stem- and progenito
Population dynamics of Arctic phytoplankton and mycoplankton reveal chytrid-mediated diatom bloom termination biorxiv.org 2026-07-08 Chytrids are unicellular fungi that infect and degrade phytoplankton as parasites or saprotrophs.
Herbivores and pathogens can modulate plant population responses to future climate conditions biorxiv.org 2026-07-08 Climate change is expected to alter plant populations not only through direct environmental shifts but also via changes in biotic interactions, such a
Short-term forecasts of Aedes aegypti relative abundance to enhance mosquito control situational awareness biorxiv.org 2026-07-07 Conventional mosquito surveillance typically relies on contemporaneous data, making it challenging to anticipate future vector surges.
Optimizing Signal Acquisition and Chemometric Pipelines for Micro NIR Plant Identification: Evaluating Spectral Backgrounds and Data Processing in Herbarium Specimens biorxiv.org 2026-07-07 Premise: Rapid and accurate plant species identification is a critical challenge exacerbated by the taxonomic impediment.
Robust analysis of comparative subcellular omics with complex designs biorxiv.org 2026-07-07 Subcellular omics technologies now allow us to obtain insights into steady-state localisation and re-localisation of biomolecules in high-throughput.
Critical reassessment of lipophilic dye labeling reveals negligible incorporation into small extracellular vesicles derived form serum-free cultured cells biorxiv.org 2026-07-08 Lipophilic dyes are widely used to track extracellular vesicles (EVs), yet their labeling efficiency toward bona fide small EVs (sEVs) remains poorly
Azacitidine Response in Myelodysplastic Syndromes is Marked by NK-like CD8 T-Cell Expansion and CXCL12+ Reticular Cell Remodeling biorxiv.org 2026-07-08 Myelodysplastic syndromes (MDS) are driven by somatic mutations in hematopoietic stem and progenitor cells (HSPCs), leading to clonal expansion and in
Reprogramming a Protein Ligase for Genetic Code Expansion biorxiv.org 2026-07-08 The ribosome's DNA-encoded production of defined polymer sequences is naturally limited to 22 amino acids.
Five Decades of Rariphotic Research: A Systematic Reviewof Trends, Biases, and Future Directions biorxiv.org 2026-07-08 The rariphotic zone, typically spanning depths of approximately 130 to 300 meters, represents a key transition between light-dependent coral reef ecos
Joint tissue explant model using psoriatic arthritis synovial fluid as a tool to capture patient-specific responses to treatments biorxiv.org 2026-07-08 Objective We developed a patient- and joint-specific explant co-culture system to model active psoriatic arthritis (PsA) and capture donor-specific ti
SELECT-seq allows Pre-Sequencing Enrichment of SNP Edits in One-Pot Single-Cell Whole-Transcriptome Sequencing biorxiv.org 2026-07-08 Advances in high-throughput sequencing have associated millions of putative genetic variants with disease.
Judging the reasons for fixations: A direct experimental method to assess the contribution of saliency and semantic factors to gaze control biorxiv.org 2026-07-07 Current debates regarding the relative contribution of saliency versus semantics to gaze control often rely on comparing the predictive power of salie
SupeRJump: Determining normal and leukemic differentiation fate through semi-supervised jump diffusion modeling biorxiv.org 2026-07-07 Single cell RNA-seq (scRNA) has provided unprecedented resolution into cellular and clonal heterogeneity.