Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite biorxiv.org 2026-07-07 During an immune response, metabolism changes dramatically.
Injectable Electrospun Hydrogel with Antimicrobial, pH Sensing Nanoparticles for Local Infection Control and Monitoring biorxiv.org 2026-07-07 Most antimicrobial drug candidates currently in development are derivatives of established antibiotic classes.
Molecular Clock Dating of Ancient Environmental DNA Reveals Damage Beyond Deamination biorxiv.org 2026-07-07 Ancient environmental DNA (aeDNA) from permafrost, lake, cave, and marine sediments provides a rich source of genetic data that captures broad perspec
Data-informed modelling captures metabolic reprogramming and reveals branch points mediating cold stress response and growth trade-offs in rice biorxiv.org 2026-07-07 Understanding stress-induced metabolic reprogramming in crop plants can inform breeding strategies and support the development of stress-resilient var
Pyramidal neuron synapses in M2 exhibit properties intermediate between prefrontal cortex and M1 synapses biorxiv.org 2026-07-07 Motor planning and control is executed by different motor areas within the neocortex.
Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer's disease using NULISA technology biorxiv.org 2026-07-07 Background: Alzheimer's disease (AD) is clinicopathologically heterogeneous.
High Dimensional Immune Profiling Reveals CD39 as a Correlate of Tuberculosis Disease Severity biorxiv.org 2026-07-07 Immune biomarkers of tuberculosis (TB) disease severity present a challenging area of research that remains poorly understood.
The glucocorticoid dexamethasone influences motility of the sulfate-reducing bacterium Desulfovibrio desulfuricans by targeting the filament cap protein FliD biorxiv.org 2026-07-07 Glucocorticoids such as dexamethasone (DXE) are first-line treatments for inflammatory bowel disease (IBD).
Zn2+ as a secondary messenger for exogenous redox potential sensed through Chemosensory Zinc-Binding (CZB) protein domains biorxiv.org 2026-07-07 Redox environments in nature are shaped by reactive oxygen species (ROS), oxygen availability, and metal ion chemistry, and exert profound effects on
Cas12a-Targeted Multiplexed Nanopore Sequencing biorxiv.org 2026-07-07 Targeted long read sequencing (LRS) of native genomic DNA (gDNA) using Oxford Nanopore Technologies (ONT) is an economically and computationally acces
Culture-Free Rapid Phenotypic Antimicrobial Susceptibility Testing for Helicobacter pylori Based on Fluorescence Rapid On-Site Evaluation Technology: A Preliminary Study biorxiv.org 2026-07-06 Background: Phenotypic antibiotic susceptibility testing (AST) for Helicobacter pylori (H.
Cross-Resistance Limits the Ability of Antimicrobial Peptide Combinations to Delay Resistance Evolution biorxiv.org 2026-07-06 Aims: Antimicrobial peptide (AMP) combinations have been proposed to delay resistance evolution, but it remains unclear what properties of a peptide p
First community challenge for automated virus taxonomy biorxiv.org 2026-07-06 The rapid rate of virus discovery renders manual curation by taxonomy experts increasingly impractical, creating a need for reliable software that can
There is no convincing evidence that Methylobacterium extorquens AM1 can produce N-deoxyschizokinen A biorxiv.org 2026-07-06 It was recently reported that Methylobacterium extorquens AM1 produces the citrate-hydroxamate siderophore N-deoxyschizokinen A, identified by LC-HRMS
Adaptation of Pseudomonas aeruginosa to the lung allograft environment in cystic fibrosis lung transplant recipients biorxiv.org 2026-07-06 Lung transplantation (LT) is the ultimate treatment option for patients suffering from end stage cystic fibrosis (CF).
Combinatorial community coalescence in early tomato assembly reveals a rhizosphere attractor in composition and abundance architecture biorxiv.org 2026-07-06 The rhizosphere microbiome plays fundamental roles in plant health and productivity, yet the ecological rules governing microbiome assembly remain poo
Virus-driven tRNA competition universally represses host genes with similar codon usage biorxiv.org 2026-07-06 Viral infection induces tRNA competition between viral and host genes, often repressing host translation.
Fitness flux in SARS-CoV-2 and influenza H3N2 biorxiv.org 2026-07-06 The tempo of viral adaptation is usually read indirectly from the composition of mutations, through measures such as dN/dS.
Multimodal temporal mapping of macrophage transcriptome remodeling during Salmonella infection biorxiv.org 2026-07-06 Macrophages are equipped to eliminate invading pathogens, yet several intracellular bacteria exploit them as replicative niches.
Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis biorxiv.org 2026-07-06 Cryptococcus neoformans is the predominant causative agent of cryptococcal meningitis in immunocompromised individuals.
EDTA v2: enabling scalable TE annotation in animal genomes biorxiv.org 2026-07-06 The Extensive de-novo TE Annotator (EDTA) automates transposable element annotation in plant genomes but lacks direct LINE/SINE detection, limiting it
Benchmarking AlphaFold and related deep learning approaches for modeling antibody and TCR antigen recognition biorxiv.org 2026-07-06 Determining the structural basis of antigen recognition by antibodies and T cell receptors (TCRs) provides critical insights into effective immune tar
Scop3P in 2026: an expanded proteomics-informed resource contextualizing phosphorylation sites through sequence, structure, mutation, and experimental provenance biorxiv.org 2026-07-06 Protein phosphorylation is a central regulatory mechanism controlling protein activity, interactions, and cellular signalling, and its dysregulation i
FORGE reveals an information spectrum encoded in RNA tertiary-structure geometry biorxiv.org 2026-07-06 Coarse RNA coordinate representations are increasingly used for inverse folding and structural annotation, but the biological information encoded in s
Accurate ΔTm Prediction Without Protein Structure Inputs for Biomolecular Stability biorxiv.org 2026-07-06 Predicting protein stability, like changes in melting temperature ({Delta}Tm) caused by mutations, is a critical task in therapeutic protein engineeri
Integrated analysis of ribosomal DNA copy number and methylation using nanopore long-read sequencing biorxiv.org 2026-07-06 Ribosomal RNA (rRNA) provides the structural and catalytic core of ribosomes and is encoded by ribosomal RNA genes (rDNA) arranged in tandem repeat ar
SpliSync: Genomic language model-driven splice site correction of long RNA sequencing reads biorxiv.org 2026-07-06 Long RNA sequencing reads are rapidly replacing short reads in transcriptomic analyses, enabling full-length transcript sequencing and better identifi
Solvent-buffer effects in molecular dynamics simulations of nucleic acids biorxiv.org 2026-07-06 Molecular dynamics simulations of nucleic acids are performed using a solvent-buffer distance of 10 [A] between the solute surface and the simulation
Solvation Shapes the Conformational Landscape of a Therapeutically Relevant SMN2 Splice-Site Defect biorxiv.org 2026-07-06 The SMN2 exon 7 5' splice-site/U1 snRNA duplex contains an A$_{-1}$ bulge that weakens splice-site recognition and represents a therapeutically releva
Unearthing a fungal giant: Dianjunaceae fam. nov., a novel Paleocene lineage of Xylariales harbouring Dianjunus rex gen. et sp. nov. biorxiv.org 2026-07-06 During mycological surveys in Yunnan Province, China, specimens of a fungus producing massive, upright stromata up to 50 cm high and individually 2.2