ORBIT: Annotation-Aware Empirical Enrichment and Semantic Reranking for Interpretable Functional-Class Recovery biorxiv.org 2026-07-07 Gene-set interpretation workflows are widely used to summarize transcriptomic and proteomic experiments, yet standard enrichment tools often return lo
Modeling human echolocation using a Kalman filter biorxiv.org 2026-07-07 Some blind individuals use echolocation, a skill that allows them to better navigate their environment using echoes from self-generated mouth clicks r
YAP/TAZ Signaling in Endothelial Cells Mediates the Pathogenesis of Abdominal Aortic Aneurysm Formation biorxiv.org 2026-07-07 Background: Abdominal aortic aneurysms (AAA) are characterized by dilation of the aorta that can lead to aortic rupture and death.
Genomic compartmentalization of pervasive sex-biased gene expression in the vine mealybug Planococcus ficus biorxiv.org 2026-07-07 The vine mealybug, Planococcus ficus, is a globally invasive pest of grapevine and a vector of leafroll viruses.
Immobilization-free chemotaxis analysis reveals the novel behavioral mode of leaving in Caenorhabditis elegans biorxiv.org 2026-07-07 Animals balance staying in a favorable environment with exploring new ones. In C.
Proliferative and Motile Cell Interplay in Glioma Invasion: Go-or-Grow Switching Caps the Invasion Speed biorxiv.org 2026-07-07 Diffuse gliomas are deadly because the individual tumor cells invade - they travel far from the imageable mass, so it is impossible to remove the tumo
High-Intensity Interval Training Remodels Adipose Tissue Inflammatory Signaling and Enhances Immunometabolic Health via microRNA Regulation biorxiv.org 2026-07-07 Sedentary behavior promotes chronic low-grade inflammation in adipose tissue, contributing to metabolic dysfunction and insulin resistance.
Neural correlates of glioma progression using implanted neural interfaces biorxiv.org 2026-07-07 High-grade glioma is an incurable brain cancer with a median survival of approximately 14 months.
Opposing GIPR brainstem circuits differentially control feeding behaviour biorxiv.org 2026-07-07 Central glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling is required for the efficacy of GIP-based obesity therapeutics, yet ho
IFN and IFN mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation biorxiv.org 2026-07-07 Type I interferons (IFN-I) and IFN{gamma} exert divergent effects during tuberculosis, but the mechanisms that determine whether macrophage activation
UVfinder: a tool to extract bryophyte sex-linked gene copies from the GoFlag408 probe set biorxiv.org 2026-07-07 Target enrichment sequencing using probe sets like GoFlag 408 has revolutionized phylogenetics, yet recent genomic data indicate that some probes may
Investigating nanostructure and -mechanics of contracting actin stress fibers by scanning ion conductance microscopy biorxiv.org 2026-07-07 Scanning ion conductance microscopy (SICM) provides gentle, non-contact cell surface imaging, but it has not been used to investigate intracellular st
Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilience biorxiv.org 2026-07-07 Endothelial cells (ECs) express organ-specific gene programs supporting tissue homeostasis and resilience.
Cross-architecture ensembling of DNA foundation models improves the precision and stability of chimera detection in long-read metagenomic bins biorxiv.org 2026-07-07 Motivation: Chimeric metagenome-assembled genomes (MAGs) that pool DNA from multiple organisms contaminate downstream analyses.
BRAID: RT-PCR-calibrated conformal intervals for splicing ΔPSI biorxiv.org 2026-07-07 Differential splicing workflows usually report a {Delta}PSI point estimate and a statistical score, but these outputs do not directly state whether th
Distinct roles for DNA- and RNA-sensing immune pathways in control of genital HSV-2 infection and restriction of neuroinvasion biorxiv.org 2026-07-07 Early control of viral infection is thought to rely on pattern-recognition receptors (PRRs) that induce interferons (IFNs) and leukocyte recruitment,
CD47 blockade augments anti-GD2 driven phagocytosis in vitro but fails to improve in vivo efficacy in immune competent, chemoresistant neuroblastoma preclinical models biorxiv.org 2026-07-07 CD47 delivers a dominant "Dont Eat Me" signal that inhibits macrophage-mediated clearance of tumour cells.
Structural Determinants of Catalytic Directionality in an AMP-Forming Acetyl-CoA Synthetase from Syntrophus aciditrophicus biorxiv.org 2026-07-07 Acetyl-coenzyme A (CoA) is a central metabolic intermediate that links carbon and energy metabolism across all domains of life.
Structure-function studies of HRIKD-{triangleup}KI, a Minimal Kinase Domain of Human Heme-Regulated Inhibitor Kinase biorxiv.org 2026-07-07 EIF2alpha kinase heme-regulated inhibitor (HRI) is a novel target for haematological malignancies with modulators reported to trigger cell death via t
Breaking the Synthesis Barrier for AI-Designed DNA Libraries biorxiv.org 2026-07-07 Designing DNA libraries is a key challenge from drug design to protein engineering and synthetic biology.
VESTA: Machine Learning-Enabled Estimation of ViscoElastic Ratios from On-Axis Spatio-Temporal ARFI Features biorxiv.org 2026-07-07 Viscoelastic characterization of tissue has significant diagnostic value in oncology, as tumor progression alters both elasticity and viscosity in way
ThermoFusion: A Multimodal Deep Learning Framework for Generalizable Prediction of Enzyme Thermostability biorxiv.org 2026-07-07 Protein thermostability is a critical property for both industrial and biomedical enzyme applications, yet experimental evaluation of mutation-induced
First estimates of the population growth rate of the parasitic honey bee mite Tropilaelaps mercedesae in Apis mellifera colonies biorxiv.org 2026-07-07 A parasitic mite of honey bee brood (Tropilaelaps mercedesae), is spreading through populations of Apis mellifera honey bees in new regions and poses
Recommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchers biorxiv.org 2026-07-07 Despite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into th
A PLK1-Directed Mitotic Genome Maintenance Network Promotes DNA Synthesis in Mitosis biorxiv.org 2026-07-07 Polo-like kinase 1 (PLK1) is a master regulator of mitosis and is known to dictate DNA repair pathway choice at this stage of the cell cycle.
The genome organizer SMC1A mediates the gene expression response in inflammation by dissociating from nuclear-speckles and redistributing to the nuclear periphery biorxiv.org 2026-07-07 Nuclear architectural proteins are increasingly recognized as multifunctional regulators whose roles extend well beyond static genome organization.
Characterisation of the RNA-Binding Properties of the MRSA β-lactam resistance enzyme PBP2a biorxiv.org 2026-07-07 Analysis of RNA-binding proteome data from different bacterial species revealed many cell wall metabolic enzymes cross-linking to RNA in vivo, hinting
PACMOS: an R package for Projection And Classification of Multi-Omic Samples biorxiv.org 2026-07-07 Motivation: Integrated multi-omic analyses have transformed our understanding of cancer biology, giving rise to data-driven molecular classifications
Ocimum gratissimum essential oil nanoemulsions as a safe topical nanoplatform for antibacterial and wound-healing activities biorxiv.org 2026-07-07 Background: Natural essential oils exhibit antimicrobial and wound-healing properties, but their therapeutic application is limited by poor water solu
Stimulus dependent modulation of perceptual filling-in is predicted by the properties of early visual cortex biorxiv.org 2026-07-07 Filling-in occurs during the perceptual disappearance of a blank figure presented on a textured background.