Real-Time Assessment of Murine Cardiac Oxygenation Using Photoacoustic Imaging biorxiv.org 2026-07-05 Background Perioperative incidents such as hypoxic cardiac injury often have subtle or nonspecific clinical manifestations.
PKCδ mediates high-fat diet-induced increased tonic GABAA receptor current in cardiac vagal motor neurons in the DMV biorxiv.org 2026-07-05 Consumption of high fat diet (HFD) is linked to reduced cardiac vagal motor output, a main contributor to progression of cardiovascular disease.
A pesticide hijacks a neurohormonal circuit to block ovulation in insects biorxiv.org 2026-07-05 The global decline of insect populations threatens ecosystem stability, yet the hidden physiological impacts of sublethal pesticide exposure remain la
Transcriptional plasticity of ventral tegmental area neurons induced after cessation of chronic cocaine exposure is required for incubation of cocaine seeking biorxiv.org 2026-07-05 Chronic cocaine triggers changes in brain function that persist long after drug taking has ceased.
Increased perceived effort during contralateral thermal heat pain is not explained by increased intracortical and corticospinal inhibition. biorxiv.org 2026-07-05 Background. Pain influences motor function and has been proposed to reduce corticospinal and intracortical excitability.
Linking Systemic Endotoxin Exposure to Retinal Microglia Migration Through Mathematical Modeling biorxiv.org 2026-07-05 Microglia are the resident immune cells of the central nervous system (CNS), including the brain, spinal cord, and retina, where they serve as the fir
Proteomic and Transcriptomic Differences in Ischemic Stroke Patients with Atrial Fibrillation Versus Carotid Atherosclerosis biorxiv.org 2026-07-05 Background: Ischemic stroke occurring in the setting of atrial fibrillation (AF) or carotid atherosclerosis (CA) may reflect distinct underlying biolo
Trauma-Exposed Adolescents Show Reduced Cortical Glutamate Modulation during Inhibitory Control with Negative Emotional Stimuli biorxiv.org 2026-07-05 Background: Childhood trauma exposure (TE) may heighten negative emotional responses, overwhelm cognitive control, and increase risk for anxiety disor
Benchmarking large language models for ACMG/AMP variant interpretation and variant calling biorxiv.org 2026-07-05 Agentic large language models are increasingly used across the genomic workflow, from variant calling to clinical interpretation, yet they are evaluat
SSUplex: fast, both-strand extraction and origin-sorting of small-subunit rRNA for environmental DNA metabarcoding biorxiv.org 2026-07-05 Ribosomal RNA metabarcoding sits at the centre of how we characterise microbial and eukaryotic communities in environmental samples, and long-read seq
A National Survey of 205 Canadian Biomedical Research Core Facilities Reveals Structural Challenges and Opportunities for Strengthening Canada's Research Ecosystem biorxiv.org 2026-07-05 Background: Canadian biomedical core facilities (BCFs) provide researchers with access to advanced tools and unique technical expertise, essential for
Individualized parcellation reveals functional boundaries in human prefrontal cortex biorxiv.org 2026-07-06 Human prefrontal cortex (PFC) supports diverse higher-order cognitive functions during task execution.
Presynaptic Terminals Dynamically Modulate Spontaneous Release Frequency During Early Synaptic Plasticity Through and Entropic Force Framework biorxiv.org 2026-07-06 Spontaneous synaptic transmission has been established as essential for the maintenance of synaptic weights during action potential-induced transmissi
Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity biorxiv.org 2026-07-06 How glial cells sense and regulate neuronal hypoactivity remains poorly understood.
Neonatal oxytocin prevents sex-specific spatial memory deficits induced by maternal separation through restoration of hippocampal synaptic plasticity in males biorxiv.org 2026-07-05 Stress during critical developmental periods causes lasting neurobiological alterations.
Behavior Differentially Shapes Spontaneous Cortical Network Dynamics Across Frequencies biorxiv.org 2026-07-06 The rapid and coordinated propagation of neural activity across a network of distributed brain regions underpins complex behavior and cognition.
A comparison of sharpening and dampening accounts of the role of expectation in shaping the neural fidelity of early visual representations biorxiv.org 2026-07-06 The natural environment is spatiotemporally structured, and the brain exploits this regularity to predict and prepare for upcoming sensory stimuli.
Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong biorxiv.org 2026-07-06 Phasic striatal dopamine has been implicated in the initiation of well-trained action sequences in reward-guided tasks.
Sphingosine 1-phosphate lyase expressed in pulmonary epithelial cells potentiates host innate defenses and alleviates influenza pathogenicity in mice biorxiv.org 2026-07-05 Influenza viruses circulate in humans, causing a substantial burden on global health.
A High Throughput SPR-Based Array for Quantitative Profiling of Glycosaminoglycan Protein Interactions biorxiv.org 2026-07-04 Glycosaminoglycans (GAGs) are linear, negatively charged, polysaccharides that mediate a wide variety of biologically critical interactions with prote
A detailed molecular picture of protein folding during active translation biorxiv.org 2026-07-04 All proteins can begin to fold on the ribosome, and many proteins critically rely on co-translational folding to attain their native conformation.
A structural trade-off balances mechanical resilience and supramolecular adaptability in type IV pili biorxiv.org 2026-07-04 Biological machines operate under mechanical load, requiring architectures that simultaneously resist force and remain functionally dynamic.
A Bottom-Up Platform for Quantitative Single-Molecule Tracking Through Bacterial Biofilm Mimics biorxiv.org 2026-07-04 Chronic infections persist in large part thanks to protection that biofilms afford their bacterial creators.
Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the MAPT-S305N model of frontotemporal dementia. biorxiv.org 2026-07-04 Progressive and chronic neuroinflammation is associated with numerous neurodegenerative diseases, including primary tauopathies such as frontotemporal
Connectome-scale self-supervised representation learning reveals neuronal organization beyond canonical labels biorxiv.org 2026-07-04 Dense electron-microscopy connectomes provide synaptic-resolution maps of neuronal structure and wiring, but learning scalable representations that in
Neural representation of hedonic valence during narrative listening biorxiv.org 2026-07-04 Hedonic valence, the intrinsic pleasantness or unpleasantness of an experience, is fundamental to human psychological functioning.
Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasis biorxiv.org 2026-07-04 Colorectal cancer remains a major cause of cancer mortality, and most microsatellite stable tumors derive little benefit from immune checkpoint blocka
PRISM : Peptide-specificity annotation of T-cell receptors with uncertainty quantification biorxiv.org 2026-07-04 Mapping T-cell receptor (TCR) sequences to their cognate peptide-major histocompatibility complex (pMHC) ligands underlies both basic immunology and T
Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses biorxiv.org 2026-07-04 Colorectal cancer (CRC) remains a leading cause of cancer mortality, with most cases refractory to immunotherapy.
Bacillus adaptation to Pseudomonas secondary metabolites enhances its root competitiveness biorxiv.org 2026-07-04 Bacillus velezensis is a widely used plant growth-promoting rhizobacterium whose effectiveness under natural conditions is strongly influenced by inte