Short-term methionine starvation induces de novo diurnal oscillations of hepatic m6A RNA methylation biorxiv.org 2026-07-10 Dietary methionine restriction has been shown to improve metabolic health and treat multiple diseases.
The Energetic Cost of Adrenergic Signaling in Primary Human Fibroblasts biorxiv.org 2026-07-10 Stress involves the activation of cellular, physiological, and emotional processes that cost energy--nothing is free in biology.
Loss of CD109 Amplifies NF-κB Signaling and Inflammatory Reprogramming in Dermal Fibroblasts biorxiv.org 2026-07-10 Fibroproliferative diseases such as systemic sclerosis are complex conditions characterized by chronic skin inflammation and progressive fibrosis, wit
miR-10b Mitigates Cardiac Fibrosis Associated with Aging and Myocardial Infarction via Attenuation of Lpar2 Signaling in Cardiac Fibroblasts biorxiv.org 2026-07-10 A impairs post-infarction cardiac repair through dysregulated fibroblast activation and excessive extracellular matrix (ECM) deposition, yet the molec
Unraveling a fine balance between ferroptosis, lipid metabolism, and hormonal protection in Leydig cell steroidogenesis biorxiv.org 2026-07-10 Leydig cells (LCs) are essential for male reproductive function due to their role in testosterone synthesis, a process critically dependent on mitocho
Machine learning-assisted Repli-Histo labeling reveals distinct transcription-dependent constraints on chromatin motion in living cells biorxiv.org 2026-07-10 Genomic DNA is wrapped around core histones to form nucleosomes, which are organized in cells from euchromatin to heterochromatin with distinct genome
Advanced Open-source Experimental-Design Tools for Microplate-Based Assays with Acoustic Liquid Handling biorxiv.org 2026-07-10 Acoustic droplet ejection (ADE) enables nanoliter-scale liquid handling for complex microplate assays, yet translating experimental designs into valid
Unmasking Supervillin: SVIL haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics biorxiv.org 2026-07-10 BackgroundRare heterozygous loss-of-function (LoF) variants in SVIL, encoding the Z-disk and costameric protein supervillin, have recently been identi
Linking transcriptome to cell behavior in real time uncovers molecular fate-asymmetry and a quiescence cycle among adult neural stem cells biorxiv.org 2026-07-10 Adult neural stem cells (NSCs) are transcriptionally heterogeneous, yet the relationship between molecular heterogeneities and individual NSC trajecto
SPARC mediates tumour-stroma intercellular communication through endosomal regulation of Delta and Notch signalling biorxiv.org 2026-07-10 Tumour progression relies on reciprocal communication between genetically altered cancer cells and surrounding stromal cells.
Semantic fragment representations for coordinate-free analysis of genomics data biorxiv.org 2026-07-10 Many genomic assays begin with individual DNA fragments, but standard analysis quickly collapses those molecules into counts over genomic intervals.
Life Under Pressure: Dissection of Cross-Phyla Metazoan Responses to Extreme Hydrostatic Pressure Reveals Pressure-Protective Heat Shock Acclimation biorxiv.org 2026-07-10 The deepest ocean is one of the most extreme environments for life on our planet, combining near-freezing temperatures, low oxygen levels, and hydrost
Chromosome, Plasmid, or Both: Short-Term Dynamics and Long-Term Outcomes of Plasmid Cost Compensation under Trade-Offs biorxiv.org 2026-07-10 Conjugative plasmids drive the dissemination of antimicrobial resistance genes and other conditionally beneficial accessory genes, but otherwise infli
DNA Methylation and Proteomic Profiling of Postmortem Brain Tissue Reveals Epigenetic Dysregulation and Neuroinflammatory in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) biorxiv.org 2026-07-10 Background: Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by FMR1 premutation CGG repeat expan
pylimma: a faithful, AnnData-native Python port of R limma for differential expression analysis biorxiv.org 2026-07-10 pylimma is a faithful Python port of limma, intended to bring one of the most widely used tools for differential expression analysis to the developing
Seamless interaction in VR: decoding user intent with eye gaze and passive brain-computer interfaces biorxiv.org 2026-07-10 Virtual reality (VR) interaction remains largely dependent on explicit motor input, limiting seamless and adaptive interaction.
Quantifying the Information Capacity of DNA Methylation as an Epigenetic Memory System biorxiv.org 2026-07-10 The information content of the genome has been extensively analyzed.
Monocyte-amplified transcriptional signatures of human diseases biorxiv.org 2026-07-10 Blood-based biomarkers discovered by machine learning often lack disease specificity and cross-population robustness for clinical applications.
ELDR-Glo, a biosensor for cell age and quiescence depth biorxiv.org 2026-07-10 Fluorescent reporters are powerful tools to reveal intercellular heterogeneity among proliferating cells.
Reduced LANCL1-AS1 in old human skeletal muscle diminishes mitochondrial activity, shortens mt-mRNA poly(A) tails, and suppresses myogenesis biorxiv.org 2026-07-10 Regeneration of skeletal muscle preserves muscle mass and function, which decline with age.
Biogenesis and antigen presentation properties of dendritic cell-derived apoptotic bodies biorxiv.org 2026-07-10 Dendritic cells (DCs) are an important type of antigen presentation cell that regulate immunity by initiating antigen-specific immunity and tolerance
METTL1 regulates glioma proliferation through internal m7G methylation of EPHA2 biorxiv.org 2026-07-10 BackgroundMethyltransferase-like 1 (METTL1) is highly expressed in organs like the pancreas but less so in the brain.
Endotome as a Source of Human Peri-Aortic Brown Adipocytes biorxiv.org 2026-07-10 Brown adipocytes (BAs) hold therapeutic promise for obesity and metabolic diseases.
TAOK3 inhibition constrains invasion, potentiates paclitaxel, and reprograms the tumor microenvironment toward anti-tumor immunity in cervical cancer biorxiv.org 2026-07-10 TAOK3 is a lesser-studied MAPK family serine/threonine kinase our group has shown to be targeted by HPV integration, suggesting a potential role in dr
Autonomous computational prioritisation of colorectal cancer vulnerabilities via multi-scale AI swarms biorxiv.org 2026-07-10 The acceleration of automated scientific discovery has been fundamentally bottlenecked by the epistemic gap between the semantic reasoning of large la
Kinome-wide CRISPR/Cas9-knockout screening reveals critical protein kinases in vasopressin V2-receptor signaling biorxiv.org 2026-07-10 Identification of signaling networks is an essential goal in systems biology.
Dynamic Histone Lysine Methylation and Demethylation in Wood Frog (Rana sylvatica) Liver During Anoxia biorxiv.org 2026-07-10 Anoxia is a major stress for most vertebrates and frequently accompanies harsh winter conditions, particularly in species that spend much of the seaso
The structure of the apo-PIWI HSP90 complex biorxiv.org 2026-07-10 PIWI proteins are members of the Argonaute family and together with piRNAs protect metazoan germlines from transposons.
Challenges in reconstituting the peroxiredoxin 2:STAT3 transient redox-relay complex in vitro biorxiv.org 2026-07-10 Peroxiredoxin 2 (Prdx2) mediates redox signaling by transferring oxidative equivalents to target proteins such as STAT3, a redox-sensitive transcripti
Insulin synthesis is sustained by Tent5 poly(A) polymerases biorxiv.org 2026-07-10 Insulin is an essential regulator of glucose homeostasis in vertebrates, and impairment of its synthesis or action leads to diabetes with severe healt