RegulomeXplorer: Interactive exploration of drug effects on subcellularly resolved proteomes biorxiv.org 2026-07-03 Mass spectrometry-based proteomics allows the quantification of drug-induced changes in protein abundance.
Age and Social Observation Effects on Theta Synchrony and Its Role in Adolescent Post-Error Control: A Computational Approach biorxiv.org 2026-07-03 Error monitoring allows for detecting mistakes and adapting behavior.
Contrasting Mitochondrial Diversity of Endemic Corbicula Clams in Sulawesis Ancient Lakes: Phylogeography and Implications for Conservation biorxiv.org 2026-07-03 The global study of freshwater clams in the genus Corbicula is frequently confounded by invasive androgenetic lineages that experience mitochondrial D
Towards genetic indicators in ectomycorrhizal fungi: estimating the effective population size biorxiv.org 2026-07-03 Ectomycorrhizal (EM) fungi are vital to forest ecosystems, supporting tree growth and survival.
Ultra-accurate sequencing reveals an extreme transmission bottleneck in a deep-sea clam symbiosis biorxiv.org 2026-07-03 Vertically transmitted symbionts experience progressive genome degradation driven by transmission bottlenecks each host generation that reduce genetic
Comparative genomics reveals shared accessory regions between members of two Fusarium species complexes virulent on garden pea biorxiv.org 2026-07-03 The contribution of accessory or conditionally dispensable chromosomes to host-specific virulence was first demonstrated in members of the Fusarium so
Evo 2's Perception of Single Nucleotide Substitutions in the Genes of Two Plant Model Organisms biorxiv.org 2026-07-03 Although DNA Large Language Models (DNA-LLMs) offer a path to decoding genetic complexity, our ability to evaluate these models is constrained by our
Genome-Wide Markers Predict Metribuzin Tolerance in Southern Soft Red Winter Wheat biorxiv.org 2026-07-03 Metribuzin is a versatile herbicide effective against various annual grasses and broadleaf weeds found in wheat fields.
Song sparrows fail to discriminate between current and historical songs biorxiv.org 2026-07-03 Song evolves rapidly in songbirds, as has been proven for a substantial number of songbird species by demonstrating acoustic differences between curre
Cognitive resilience despite metabolic dysfunction after adolescent-onset high-fat high-sucrose diet exposure in rats biorxiv.org 2026-07-03 Adolescence is a sensitive period during which unhealthy diets may shape metabolic health and cognition.
A bistable UV-sensitive opsin from a reef building coral showing a switchable and tunable regulation of Gs-signaling by different wavelengths of light biorxiv.org 2026-07-03 Cnidarians possess large number of opsins in their genomes for their various photoreceptive functions.
Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes biorxiv.org 2026-07-03 Generating bioengineered cartilage that recapitulates the depth-dependent phenotype, structure, and function of native articular cartilage remains a c
AART enables fast and accurate cross-platform proteomic translation biorxiv.org 2026-07-03 Plasma proteomic profiling has been widely used for biomarker discovery, disease prediction and diagnosis, and patient stratification.
Scalable and rare-variant aware genome inference across the 1kGP cohort biorxiv.org 2026-07-03 Pangenome graphs built from haplotype-resolved de novo assemblies enable accurate analysis of genetic variation.
Disease Stage- and Risk-Associated RNA Editing Signatures in Acute Myeloid Leukemia and Their Utility for Peripheral Blood-Based Assessment biorxiv.org 2026-07-03 RNA editing is a widespread post-transcriptional regulatory mechanism, but its role in acute myeloid leukemia (AML) remains incompletely understood.
Location dependence of protein intrinsic disorder in Drosophila melanogaster biorxiv.org 2026-07-03 The relevance of protein structural flexibility in function remains contested, but experimental and computational evidence continues to accumulate.
Neuraminidase-Mediated Desialylation Modulates Red Blood Cell Aggregation biorxiv.org 2026-07-03 The glycocalyx of red blood cells (RBCs), a negatively charged surface layer rich in sialic acid residues, plays a crucial role in modulating RBC aggr
Using spIsoNet to address the preferred-orientation problem in cryoEM reconstructions biorxiv.org 2026-07-03 Cryogenic electron microscopy (cryoEM) is now routinely used for high-resolution structure determination of biological macromolecules.
Maternal effects shape scale-dependent convergence in gut microbial responses to environmental change biorxiv.org 2026-07-03 Animals can experience environmental variability across multiple temporal scales, from predictable within-year seasonal fluctuations to rarer, irregul
When suitable habitat is not enough: climate change, habitat loss, and dispersal limitation increase the vulnerability of bald-headed uakaris (Cacajao sp.) in the Amazon Rainforest biorxiv.org 2026-07-03 Aims: Species' distributions are determined by the interplay between ecological niche and dispersal ability, constrained by biogeographical barriers.
Resolving symmetry-masked allosteric cooperativity in the M. tuberculosis proteasome core particle biorxiv.org 2026-07-03 The 20S proteasome core particle (CP) is a stacked 7-{beta}7-{beta}7-7 assembly in which the central {beta}-rings host fourteen catalytic active sites
A generalizable interface-seeded framework for de novo design of functional oligomers biorxiv.org 2026-07-03 Protein oligomers are ubiquitous in biological systems and essential for function.
Modeling mosquito control strategies and their effect on pathogen transmission biorxiv.org 2026-07-03 The mosquito Aedes albopictus is a competent vector for the transmission of several arboviruses and is currently spreading across many continents.
Full-length COI barcodes improve eDNA metabarcoding data denoising relative to mini-barcodes biorxiv.org 2026-07-03 Animal COI (mitochondrial cytochrome oxidase I) metabarcoding of environmental DNA (eDNA) is increasingly used to assess biodiversity in complex subst
Microbial, dietary insect, and pathogen communities in fresh and decomposing guano of anthropic little brown bat (Myotis lucifugus) maternity colonies biorxiv.org 2026-07-03 The guano of insectivorous bats holds ecological information that can be assessed non-invasively to characterize the gut microbiome and diet, alongsid
Substrate-dependent epistasis probes active site intramolecular wiring biorxiv.org 2026-07-03 Enzyme adaptation toward novel substrates involves the rewiring of intramolecular residue networks, yet how this rewiring differs across multiple subs
Lung hypoperfusion stimulates liquid absorption in alveoli biorxiv.org 2026-07-03 Tissue hypoperfusion is common in clinical settings, but how tissues respond to hypoperfusion on a microphysiological scale is not clear.
An optimized "hypoxia in a pill" regimen reverses neurodegenerative disease phenotypes in multiple preclinical models biorxiv.org 2026-07-03 A growing body of pre-clinical research has demonstrated the therapeutic potential of chronic, continuous hypoxia (11% FIO2) for treating both rare an
Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotection biorxiv.org 2026-07-03 Human genetics implicates innate immunity as a key modifier of tau toxicity, yet human-specific neuroimmune mechanisms remain difficult to test in viv
The NORAD-pumilio regulatory axis links lncRNA dysregulation to tau propagation-associated phenotypes biorxiv.org 2026-07-03 Long non-coding RNAs (lncRNAs) are increasingly implicated in neurodegenerative disease, yet their roles in tauopathy remain poorly understood.