First Lithic Age Caribbean genomes document pre-Ceramic genetic continuity and affinities to Central America and northern South America biorxiv.org The population history of the Caribbean’s first inhabitants has been challenging to reconstruct because few human remains are known from the region’s
Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest and a shared enhancer in mice. biorxiv.org KLF14 acts as a master regulator of gene expression in adipose tissue and variants at the human KLF14 gene show strong and reproducible association wi
δ-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20 biorxiv.org Coordinated maturation of diverse neural cell types drives mammalian cortical circuit development.
Single-stranded telomeric repeats segregate into spatial compartments within ALT-associated PML bodies biorxiv.org Alternative lengthening of telomeres (ALT)-associated PML bodies (APBs) concentrate single-stranded (ss) telomeric DNA and RNA species that are critic
SUMO paralogues differentially affect phase separation and aggregation of intrinsically disordered proteins biorxiv.org SUMO, the small ubiquitin-like modifier, modulates interactions of folded proteins, but also affects the dynamics of biomolecular condensates.
Neural tracking of biological motion rhythms in early infancy: links to caregiver touch-related behaviours and attitudes biorxiv.org Infant environments are rich in rhythms, many of which are social in nature.
Motor Sequence Learning in Children and Adults: Age Differences in the Time Course of Brain Activation and Representational Stability biorxiv.org
Beyond Onset Timing: Longer Sound Envelope Duration Enhances Neural Representation of the Musical Beat biorxiv.org
Auditory Working Memory Mediates the Relationship between Musical Sophistication and Speech-in-noise Perception biorxiv.org
HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease biorxiv.org
AN OPTIMIZED AND DRUGGABLE HUMAN KERATINOCYTE AND IPSC-DERIVED SENSORY NEURON CO-CULTURE SYSTEM FOR ATOPIC ITCH biorxiv.org
A region-specific murine intestinal monolayer platform for assessing iron form-dependent transepithelial transport biorxiv.org
Collagen crosslinking and organizational patterns reflect common disease processes in idiopathic pulmonary fibrosis and non-resolving acute respiratory distress syndrome biorxiv.org
PARP1 catalytic domain mutations drive high-level resistance to saruparib while preserving DNA damage response vulnerabilities biorxiv.org
SOCS1 expression in prostate epithelial cells is essential for tissue homeostasis and tumor suppression biorxiv.org
Neuroendocrine-like/EMT dedifferentiation mediates resistance to EGFR inhibitors via the NRG1/HER3 axis biorxiv.org
An assessment of normalization and differential expression methods for miRNA-seq analysis using a realistic benchmark dataset biorxiv.org
Disagreement between demultiplexing methods reveals structured cell quality gradients in multiplexed single-cell data biorxiv.org
Monocyte-Mimetic Nanoprobe Enables Longitudinal MRI of Atherosclerotic Inflammatory Dynamics biorxiv.org
WATER reveals heterochrony of molecular programs underlies developmental failure caused by minor spliceosome inhibition biorxiv.org
Spinal lumen remodeling under the control of Gli signaling mechanically drives roof plate cells extension biorxiv.org
Desmoglein-3 modulates p38MAPK and ERK signaling responses through the mechano-sensitive channel Piezo1 biorxiv.org
Calmodulin requires calcium to be a constitutive component of the spindle pole bodies in fission yeast biorxiv.org
Evaluating non-lethal tissue suitability for telomere length measurement in the Japanese eel biorxiv.org