Benthic diatoms navigate shear flows via hydrodynamic rolling and active gliding biorxiv.org Navigating fluid flow is a fundamental challenge for microbial life across diverse aquatic environments.
Dual curvature sensing governs cell orientation and curvotaxis biorxiv.org Cells lying in a curved environment can respond to the surface curvature by reorienting their shape.
Frequency-Dependent Modulation of Adult Hippocampal Neurogenesis, Memory, and BDNF Signaling by Low-Intensity Focused Ultrasound biorxiv.org Adult hippocampal neurogenesis plays a central role in learning, memory formation, and adaptive neural plasticity, making it an attractive target for
Ultrasound-led stratification of carpal tunnel syndrome reveals structure-function mismatch biorxiv.org The severity stratification of carpal tunnel syndrome (CTS) relies on ultrasound morphological markers and electromyography.
Sequence-Defined Digital Bottlebrush Polymers for Programmable Oligonucleotide Delivery biorxiv.org Oligonucleotide therapeutics hold transformative potential, yet their clinical translation is hindered by delivery barriers, including rapid renal/hep
A Multi-Omics Atlas of Naturally Occurring Myelomeningocele in a Large-Animal Model Reveals Heritable Architecture. biorxiv.org Neural tube closure relies on tightly coordinated morphogenetic programs integrating convergent extension, apical constriction of the neuroepithelium,
Coevolution and synchronized evolutionary rates in aphid dual endosymbiosis biorxiv.org Many insects depend on obligate endosymbionts for their nutrition.
Whole body elongation drives coordinated vertebral shape evolution in Lake Malawi cichlid fishes biorxiv.org
Phenotypic integration and morph-specific strategies in a colour-polymorphic lizard, Ctenophorus pictus. biorxiv.org
Remote underwater photographs reveal environmental correlations and patterns in reef manta ray habitat use in Laamu Atoll, Maldives biorxiv.org
Naked antisense oligonucleotides remain endolysosomally sequestered despite induced membrane damage biorxiv.org
Exosome-like biogenesis from the Golgi releases extracellular vesicles lacking conventional tetraspanins that mediate immune evasion in cancer biorxiv.org
RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed bymultiplexed optogenetics and biosensor imaging biorxiv.org
GRK-dependent ACKR3 endocytosis and chemokine scavenging is independent of receptor phosphorylation and beta-arrestin biorxiv.org
Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport biorxiv.org
Endogenous network modeling reveals mechanisms of repair Schwann cell decline and potential recovery targets biorxiv.org
AAV tools enable functional modulation and readout of central and peripheral nervous systems in spiny mice biorxiv.org
Single-cell quantification of the iron-neuromelanin balance in dopaminergic neurons across the lifespan biorxiv.org
Metagenomics-enabled proteomics reveals how AMF and PSB co-inoculation reshapes tomato rhizosphere dynamics across growth stages biorxiv.org
Engineering a 3D Lung Co-culture Platform to Model Epithelial-Fibroblast Interactions in Pulmonary Fibrosis biorxiv.org
Divergent signaling profiles in mTOR gain-of-function Smith-Kingsmore syndrome (SKS) and TSC2 deficiency biorxiv.org
Preserved Type 2 Immune Cell Plasticity in Human Obesity and Differential Immune Reconstitution After Bariatric Surgery biorxiv.org Background Obesity disrupts type 2 immune cell populations in white adipose tissue, replacing the homeostatic network of group 2 innate lymphoid cells
DynoSys 2.0: Graph-Based Modeling of Dynamic Risk States and System Transitions in Human Behaviours Development biorxiv.org Human behavioral and mental health outcomes arise from interactions among genetic, environmental, and neurobiological systems.
Cave-dwelling Planariidae in Croatia exhibit differing levels of cave trait evolution biorxiv.org The Dinaric karst of Croatia encompasses a network of over 10,000 caves and represents one of the world’s most important subterranean biodiversity hot
upSPLAT: Early-Barcoded Library Preparation for Cost-Effective Population-Scale Genomics biorxiv.org Advances in high-throughput sequencing have substantially reduced sequencing costs, yet library preparation remains a major financial and logistical b