The Joint Impact of Deleterious Mutations, Dominance, and Gene Flow on Linked Neutral Variation in Structured Populations biorxiv.org
Circadian Clock Programming of Anticipatory Antiviral Immunity Gates Enteric Virus Infection Susceptibility biorxiv.org
Relational biological structure improves fine-mapping of causal GWAS variants under weak signal biorxiv.org
Rapid connectivity alterations of thalamic nuclei during initial learning of goal-directed behaviour biorxiv.org The thalamus is essential for learning, dynamically engaging with other subcortical and cerebral cortex regions throughout the learning process.
Pyramidal-cell-specific hemispheric asymmetry shapes dorsoventral CA1 dynamics during rest and exploratory behavior biorxiv.org
Continuous negative autoregulation fine-tunes dosage-sensitive transcription factor expression to maintain post-mitotic neuron identity biorxiv.org
Noisy information about the environment: A source of individual differences within and across generations biorxiv.org
Dendrite-soma interactions in cultured hippocampal neurons form non-random structural motifs with local presynaptic enrichment and strengthening biorxiv.org
Spatially resolved transcriptomic identification of thousands of neurons recorded in vivo. biorxiv.org
Benchmarking Short-Read ITS2 and Full-Length ITS Sequencing Reveals Pipeline-Dependent Biases in Indoor Fungal Community Profiling biorxiv.org
Stepwise assembly of virulence-associated traits in the intracellular pathogen Coxiella burnetii biorxiv.org Coxiella burnetii is the only member of the order Legionellales known to primarily infect vertebrates.
Metagenome-guided substrate selection enriches Terriglobus, reveals co-occurring taxa, and enables isolation of a novel species biorxiv.org Microbes that remain uncultivated occupy nearly every ecosystem on the planet; this is particularly true in soils, where despite their prevalence, the
Influence of non-content instructor talk on students' motivation-related outcomes in laboratory courses biorxiv.org Course-based undergraduate research experiences (CUREs) can expand undergraduates' access to research and motivate students to stay in science.
Deciphering conformational preferences of RNA in protein-RNA recognition biorxiv.org Conformational plasticity of RNAs plays important roles in recognizing RNA-binding proteins, and is often modulated by their binding partners.
An Exponential Scale Mixture Model for Metatranscriptomics Data with Application to Inflammatory Bowel Disease biorxiv.org
Environmental microbial communities and host selection shape larval microbiomes biorxiv.org Ocean warming is altering abiotic environments and biotic interactions experienced by marine organisms, where sensitive early developmental windows oc
Differential collagen crosslinking and network organization creates distinct tissue remodeling patterns in fibrosis and COPD biorxiv.org Collagens are key components of the extracellular matrix (ECM) that play a crucial role in maintaining structure, strength, and function of the lungs.
Lipid Hydrogen Stable Isotope Probing Reveals Decadal-Scale Generation Times for Archaea in Hot Spring Sediments biorxiv.org Quantifying the lipid biosynthesis rate of archaea in hot spring sediments is necessary to interpret the abundance, isotopic patterns, and environment
SroA links SigS-dependent stress signaling to metabolic remodeling in Staphylococcus aureus biorxiv.org Staphylococcus aureus encounters diverse environmental conditions during colonization and infection, including fluctuations in nutrient availability,
Systematic profiling of WD40 proteins reveals Wcp1, a cyclophilin linking CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformans biorxiv.org WD40 domains are major protein–protein interaction (PPI) scaffolds, yet their contributions to fungal pathogenicity remain poorly defined.
Bacteriophage P22 virus-like particles as nanoscale protein scaffolds for plant synthetic biology biorxiv.org Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools.
Symmetry Analysis and Ancestral Sequence Reconstruction Reveal a Symmetrical Translocation Pathway and Activity Determinants of ZIP Metal Transporter biorxiv.org
De novo design of transmembrane accessory subunits for fold stabilization and expansion biorxiv.org Transmembrane (TM) proteins play essential roles in biology as transporters, ion channels, chaperones, enzymes, and mediators of signal transduction.